2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0830BS
    Palmitic acid-13C sodium 201612-54-6 98%
    Palmitic acid-13C (sodium) is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-13C sodium
  • HY-N0830S1
    Palmitic acid-15,15,16,16,16-d5 285979-77-3 98%
    Palmitic acid-15,15,16,16,16-d5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-15,15,16,16,16-d5
  • HY-N0830S8
    Palmitic acid-9,10-d2 78387-70-9 98%
    Palmitic acid-9,10-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-9,10-d2
  • HY-N1428AR
    Citric acid monohydrate (Standard) 5949-29-1
    Citric acid monohydrate (Standard) is the analytical standard of Citric acid monohydrate (HY-N1428A). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid monohydrate (Standard)
  • HY-N1428S2
    Citric acid-13C2 224054-26-6 98%
    Citric acid-13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid-13C2
  • HY-N1584BR
    Halofuginone hydrochloride (Standard) 1217623-74-9
    Halofuginone (hydrochloride) (Standard) is the analytical standard of Halofuginone (hydrochloride). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[4].
    Halofuginone hydrochloride (Standard)
  • HY-N16662A
    threo-Anethole glycol 112018-74-3
    threo-Anethole glycol (Compound 12) is an aromatic diol compound found in Foeniculi Fructus. threo-Anethole glycol has potential antioxidant activity and can be used for the researches of inflammation, cardiovascular and neurological disease.
    threo-Anethole glycol
  • HY-N2021AR
    Phosphoramidon Disodium (Standard) 164204-38-0
    Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process.
    Phosphoramidon Disodium (Standard)
  • HY-N6020AR
    (+)-Butin (Standard) 74628-42-5
    (+)-Butin (Standard) is the analytical standard of (+)-Butin (HY-N6020A). This product is intended for research and analytical applications. (+)-Butin is the R-enantiomer of Butin (HY-N6020B). Butin is a bioactive flavonoid. Butin can be isolated from the heartwood of Dalbergia cocos. Butin exhibits potent antioxidant, antiplatelet, and anti-inflammatory activities.
    (+)-Butin (Standard)
  • HY-N7142S3
    DL-Norepinephrine-d6 1219908-83-4
    DL-Norepinephrine-d6 is the deuterium labeled DL-Norepinephrine (HY-N7142). DL-Norepinephrine is a synthetic phenylethylamine. DL-Norepinephrine is a neurotransmitter targets α1 and β1 adrenoceptors. DL-Norepinephrine mimics the sympathomimetic actions of the endogenous norepinephrine. DL-Norepinephrine has an increasing effect on subendocardial oxygen tension.
    DL-Norepinephrine-d6
  • HY-NP0223A
    Human apolipoprotein AI 98%
    Human Apolipoprotein AI is a high density lipoprotein with anti-atherogenic properties. Human Apolipoprotein AI contains a series of highly homologous amphiphatic α-helices.
    Human apolipoprotein AI
  • HY-NP0223B
    Human apolipoprotein AI, low endotoxin level 98%
    Human apolipoprotein AI, low endotoxin level is a high density lipoprotein with anti-atherogenic properties. Human apolipoprotein AI, low endotoxin level contains a series of highly homologous amphiphatic α-helices.
    Human apolipoprotein AI, low endotoxin level
  • HY-NP0223C
    Human apolipoprotein AII 98%
    Human apolipoprotein AII is the major apolipoproteins of HDL that is synthesised in liver. Human apolipoprotein AII is a 100 amino acid (aa) precursor preproapo A-II. Preproapo A-II is cleaved co-translationally (18 aa) to proapo A-II.
    Human apolipoprotein AII
  • HY-NP0231B
    Human haptoglobin, low endotoxin 98%
    Human haptoglobin, low endotoxin is the most prominent protein in blood, transporting O2 and facilitating reactive oxygen and nitrogen species detoxification. The human gene for haptoglobin consists of three structural alleles: Hp1F, Hp1S and Hp2.
    Human haptoglobin, low endotoxin
  • HY-P0206S1
    RPP-(Gly-13C2,15N)-FSPFR TFA 98%
    RPP-(Gly-113C2,15N)-FSPFR TFA is 13C- and 15N-labeled Bradykinin (HY-P0206). Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
    RPP-(Gly-13C2,15N)-FSPFR TFA
  • HY-P10897A
    SjDX5-271v
    SjDX5-271v is a negative control of SjDX5-271 (HY-P10897). SjDX5-271 is a small 3 kDa peptide. SjDX5-271 inhibits the TLR4/MyD88/NF-κB signaling pathway. SjDX5-271 induces cell polarization. SjDX5-271 alleviats hepatic inflammation. SjDX5-271 protects mice against liver ischemia-reperfusion injury.
    SjDX5-271v
  • HY-P990088
    Sotiburafusp alfa 2637466-37-4 98%
    Sotiburafusp alfa is a bispecific fusion protein, which is a humanized VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) fused via the peptide linker 101GGSGGSGGSGGSGGS115 to the N-terminus of the heavy chain (116-564) of a humanized IgG1-kappa anti-human PD-L1 heavy chain variant L352>A, L353>A. Sotiburafusp alfa is also an angiogenesis inhibitor.
    Sotiburafusp alfa
  • HY-P990731
    Canvircept 2833647-10-0 98%
    Canvircept is a recombinant fusion protein comprising an angiotensin-converting enzyme 2 (ACE2) fused to a human IgG1 Fc.
    Canvircept
  • HY-P991117
    Amrecibart 3008610-20-3 98%
    Amrecibart is an anti-coagulation factor 11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    Amrecibart
  • HY-P991124
    Cenvacibart 3008610-21-4 98%
    Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases.
    Cenvacibart
Cat. No. Product Name / Synonyms Application Reactivity